Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 17 November 1967:
Vol. 158. no. 3803, pp. 936 - 937
DOI: 10.1126/science.158.3803.936
Prev | Table of Contents | Next

Articles

Enzyme Concentrations in Tissues

Paul A. Srere 1

1 Veterans Administration Hospital and Department of Biochemistry, University of Texas, Southwestern Medical School, Dallas

Apparent enzyme concentrations in cells and in mitochondria are calculated from data available in the literature. These values are 10-6 to 10-5 moles per kilogram of tissue. It is pointed out that these concentrations are much higher than those used in enzymatic studies in vitro. Metabolic interpretations of experiments in vitro should consider this additional departure from conditions in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Myogenin and oxidative enzyme gene expression levels are elevated in rat soleus muscles after endurance training.
P. M. Siu, D. A. Donley, R. W. Bryner, and S. E. Alway (2004)
J Appl Physiol 97, 277-285
   Abstract »    Full Text »    PDF »
Reduction of Fe(III) Ions Complexed to Physiological Ligands by Lipoyl Dehydrogenase and Other Flavoenzymes in Vitro: IMPLICATIONS FOR AN ENZYMATIC REDUCTION OF Fe(III) IONS OF THE LABILE IRON POOL.
F. Petrat, S. Paluch, E. Dogruoz, P. Dorfler, M. Kirsch, H.-G. Korth, R. Sustmann, and H. de Groot (2003)
J. Biol. Chem. 278, 46403-46413
   Abstract »    Full Text »    PDF »
The Yeast Mitochondrial Carrier Leu5p and Its Human Homologue Graves' Disease Protein Are Required for Accumulation of Coenzyme A in the Matrix.
C. Prohl, W. Pelzer, K. Diekert, H. Kmita, T. Bedekovics, G. Kispal, and R. Lill (2001)
Mol. Cell. Biol. 21, 1089-1097
   Abstract »    Full Text »    PDF »
Cytoarchitecture of size-excluding compartments in living cells.
D. Provance, A McDowall, M Marko, and K Luby-Phelps (1993)
J. Cell Sci. 106, 565-577
   Abstract »    PDF »
Metabolite transfer via enzyme-enzyme complexes.
D. Srivastava and S. Bernhard (1986)
Science 234, 1081-1086
   Abstract »    PDF »
Lactate Dehydrogenase Isozymes: Kinetic Properties at High Enzyme Concentrations.
T. Wuntch, R. F. Chen, and E. S. Vesell (1970)
Science 167, 63-65
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)