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Science 10 November 1967:
Vol. 158. no. 3802, pp. 793 - 794
DOI: 10.1126/science.158.3802.793
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Articles

Hydraulic Compression of Mice to 166 Atmospheres

J. A. Kylstra 1, R. Nantz 1, J. Crowe 1, W. Wagner 1, and H. A. Saltzman 1

1 Departments of Medicine and Physiology, Duke University Medical Center, Durham, North Carolina

Hydraulic uniform compression elicited tremors, uncoordinated limb movements, and tonic convulsions in liquid-breathing mice at pressures ranging from 50 to 100 atmospheres. Such abnormal muscular activity was observed neither in control animals nor in mice caudally to a spinal transection. Uniform compression of isolated preparations of mouse muscle in saline failed to contract at pressures up to 200 atmospheres.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)