Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 October 1967:
Vol. 158. no. 3800, pp. 490 - 492
DOI: 10.1126/science.158.3800.490
Prev | Table of Contents | Next

Articles

"Blastokinin": Inducer and Regulator of Blastocyst Development in the Rabbit Uterus

R. Sivarama Krishnan 1 and Joseph C. Daniel Jr. 1

1 Institute for Developmental Biology, University of Colorado, Boulder

A protein fraction that induces blastulation of rabbit morula and stimulates blastocyst development has been isolated from the uterus of the rabbit at early pregnancy. Partial purification of this fraction indicates that the activity is restricted to a single homogeneous protein component. The term "blastokinin" is proposed to describe the compound.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Use of Uteroglobin for the Engineering of Polyvalent, Polyspecific Fusion Proteins.
E. Ventura, F. Sassi, S. Fossati, A. Parodi, W. Blalock, E. Balza, P. Castellani, L. Borsi, B. Carnemolla, and L. Zardi (2009)
J. Biol. Chem. 284, 26646-26654
   Abstract »    Full Text »    PDF »
Uteroglobin: A Steroid-Inducible Immunomodulatory Protein That Founded the Secretoglobin Superfamily.
A. B. Mukherjee, Z. Zhang, and B. S. Chilton (2007)
Endocr. Rev. 28, 707-725
   Abstract »    Full Text »    PDF »
Transgenic mice overexpressing hepatocyte growth factor in the airways show increased susceptibility to lung cancer.
L. P. Stabile, J. S. Lyker, S. R. Land, S. Dacic, B. A. Zamboni, and J. M. Siegfried (2006)
Carcinogenesis 27, 1547-1555
   Abstract »    Full Text »    PDF »
Uteroglobin Inhibits Prostaglandin F2{alpha} Receptor-mediated Expression of Genes Critical for the Production of Pro-inflammatory Lipid Mediators.
A. K. Mandal, R. Ray, Z. Zhang, B. Chowdhury, N. Pattabiraman, and A. B. Mukherjee (2005)
J. Biol. Chem. 280, 32897-32904
   Abstract »    Full Text »    PDF »
Increased Susceptibility of Mice Lacking Clara Cell 10-kDa Protein to Lung Tumorigenesis by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a Potent Carcinogen in Cigarette Smoke.
Y. Yang, Z. Zhang, A. B. Mukherjee, and R. I. Linnoila (2004)
J. Biol. Chem. 279, 29336-29340
   Abstract »    Full Text »    PDF »
IFN-{gamma} Stimulates the Expression of a Novel Secretoglobin That Regulates Chemotactic Cell Migration and Invasion.
M. S. Choi, R. Ray, Z. Zhang, and A. B. Mukherjee (2004)
J. Immunol. 172, 4245-4252
   Abstract »    Full Text »    PDF »
Steroid Hormones, Endometrial Gene Regulation and the Sp1 Family of Proteins.
G. Krikun and C. J. Lockwood (2002)
Reproductive Sciences 9, 329-334
   Abstract »    PDF »
Full-Length Complementary DNA and the Derived Amino Acid Sequence of Horse Uteroglobin.
F. Muller-Schottle, A. Bogusz, J. Grotzinger, A. Herrler, C. A. Krusche, K. Beier-Hellwig, and H. M. Beier (2002)
Biol Reprod 66, 1723-1728
   Abstract »    Full Text »    PDF »
Characterization and Cloning of Two Isoforms of Heteroglobin, a Novel Heterodimeric Glycoprotein of the Secretoglobin-Uteroglobin Family Showing Tissue-specific and Sex Differential Expression.
J. Alvarez, J. Vinas, J. M. M. Alonso, J. P. Albar, K. Ashman, and P. Dominguez (2002)
J. Biol. Chem. 277, 233-242
   Abstract »    Full Text »
Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells.
T. M. Watson, S. D. Reynolds, G. W. Mango, I.-M. Boe, J. Lund, and B. R. Stripp (2001)
Am J Physiol Lung Cell Mol Physiol 281, L1523-L1530
   Abstract »    Full Text »    PDF »
Expression of uteroglobin in the human endometrium.
F. Muller-Schottle, I. Classen-Linke, J. Alfer, C. Krusche, K. Beier-Hellwig, K. Sterzik, and H. M. Beier (1999)
Mol. Hum. Reprod. 5, 1155-1161
   Abstract »    Full Text »    PDF »
Loss of transformed phenotype in cancer cells by overexpression of the uteroglobin gene.
Z. Zhang, G. C. Kundu, D. Panda, A. K. Mandal, G. Mantile-Selvaggi, A. Peri, C.-J. Yuan, and A. B. Mukherjee (1999)
PNAS 96, 3963-3968
   Abstract »    Full Text »    PDF »
Hormone-dependent Recruitment of NF-Y to the Uteroglobin Gene Enhancer Associated with Chromatin Remodeling in Rabbit Endometrial Epithelium.
A. Scholz, M. Truss, and M. Beato (1999)
J. Biol. Chem. 274, 4017-4026
   Abstract »    Full Text »    PDF »
Uteroglobin (UG) Suppresses Extracellular Matrix Invasion by Normal and Cancer Cells That Express the High Affinity UG-binding Proteins.
G. C. Kundu, A. K. Mandal, Z. Zhang, G. Mantile-Selvaggi, and A. B. Mukherjee (1998)
J. Biol. Chem. 273, 22819-22824
   Abstract »    Full Text »    PDF »
Hormone-induced Recruitment of Sp1 Mediates Estrogen Activation of the Rabbit Uteroglobin Gene in Endometrial Epithelium.
A. Scholz, M. Truss, and M. Beato (1998)
J. Biol. Chem. 273, 4360-4366
   Abstract »    Full Text »    PDF »
cis-Acting Elements Involved in the Regulation of Mouse Clara Cell-specific 10-kDa Protein Gene.
M. K. Ray, S. W. Magdaleno, M. J. Finegold, and F. J. DeMayo (1995)
J. Biol. Chem. 270, 2689-2694
   Abstract »    Full Text »    PDF »
Suppression of epididymal sperm antigenicity in the rabbit by uteroglobin and transglutaminase in vitro.
D. Mukherjee, A. Agrawal, R Manjunath, and A. Mukherjee (1983)
Science 219, 989-991
   Abstract »    PDF »
Cell Culture of Mammalian Endometrium and Synthesis of Blastokinin in vitro.
G. L. Whitson and F. A. Murray (1974)
Science 183, 668-670
   Abstract »    PDF »
A Two-receptor Pathway for Catabolism of Clara Cell Secretory Protein in the Kidney.
R. Burmeister, I.-M. Boe, A. Nykjaer, C. Jacobsen, S. K. Moestrup, P. Verroust, E. I. Christensen, J. Lund, and T. E. Willnow (2001)
J. Biol. Chem. 276, 13295-13301
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)