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Science 29 September 1967:
Vol. 157. no. 3796, pp. 1567 - 1569
DOI: 10.1126/science.157.3796.1567
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Articles

Delayed Hypersensitivity in Man: A Correlate in vitro and Transfer by an RNA Extract

Daniel E. Thor 1

1 Departments of Medicine and Microbiology, University of Illinois at the Medical Center, Chicago 60680

The migration of sensitized human monocytic-phagocytic cells from lymph-node tissue-culture suspensions was regularly and specifically inhibited by purified protein derivative or histoplasmin. Moreover, when nonsensitive cells were incubated with an RNA extract from lymph nodes of donors sensitive to purified protein derivative, histoplasmin, or both, the migration of these cells was specifically inhibited by these antigens. Ribonuclease inactivated the RNA extract.


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D. L. MORTON, C. M. HASKELL, Y. H. PILCH, F. C. SPARKS, and W. D. WINTERS (1972)
Ann Intern Med 77, 431-454
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Science. ISSN 0036-8075 (print), 1095-9203 (online)