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Science 8 September 1967:
Vol. 157. no. 3793, pp. 1187 - 1189
DOI: 10.1126/science.157.3793.1187
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Articles

Prostaglandins: Localization in Subcellular Particles of Rat Cerebral Cortex

K. Kataoka 1, P. W. Ramwell 1, and Sheila Jessup 1

1 Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts

Homogenates of rat cerebral cortex contain material corresponding to prostaglandins E1, E2, F1agr, and F2agr which are concentrated mainly in the light microsomal and mitochondrial fractions. Only the former fraction exhibits significant ability to synthesize prostaglandins E1 and F1agr from bis-homo-ggr-linolenic acid. After subfractionation of the crude mitochondrial fraction, prostaglandin E and F material is found mainly in the cholinergic and noncholinergic nerve endings. We conclude that the nerve endings are a storage site, whereas the light microsomes are the site of synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Prostaglandins and the Central Nervous System.
F. Coceani (1974)
Arch Intern Med 133, 119-129
   Abstract »    PDF »
Prostaglandins E1 and E2 Antagonize Norepinephrine Effects on Cerebellar Purkinje Cells: Microelectrophoretic Study.
B. J. Hoffer, G. R. Siggins, and F. E. Bloom (1969)
Science 166, 1418-1420
   Abstract »    PDF »


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