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Science 1 September 1967:
Vol. 157. no. 3792, pp. 1060 - 1062
DOI: 10.1126/science.157.3792.1060
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Articles

Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity

Nancy H. Ruddle 1 and Byron H. Waksman 1

1 Department of Microbiology, Yale University, New Haven, Connecticut

Lymph node cells from inbred rats having delayed sensitivity to soluble proteins inhibit growth of syngeneic or allogeneic fibroblasts in the presence of specific antigen. A relation is suggested between this in vitro phenomenon and other systems believed to be specific manifestations of delayed hypersensitivity.


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