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Science 25 August 1967:
Vol. 157. no. 3791, pp. 927 - 929
DOI: 10.1126/science.157.3791.927
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Articles

Collagen Proline Hydroxylase in Wound Healing, Granuloma Formation, Scurvy, and Growth

Emilio Mussini 1, John J. Hutton Jr. 1, and Sidney Udenfriend 1

1 Laboratory of Clinical Biochemistry, National Heart Institute, Bethesda, Maryland 20014

Compared to homologous tissues from adult animals, rapidly growing embryonic and fetal tissues contain large amounts of collagen proline hydroxylase. Lung and skin from scorbutic guinea pigs contain one-third as much enzyme as normal tissues do. A rapid increase in proline hydroxylase occurs on the 2nd day of formation of granuloma after injection of carrageenan and on the 4th day of wound healing. The increase in enzyme activity is associated with the onset of collagen biosynthesis and deposition.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The B Vitamins and Vitamin C in Human Nutrition: II. 'Conditional' B Vitamins and Vitamin C.
J. R. Moran and H. L. Greene (1979)
Arch Pediatr Adolesc Med 133, 308-314
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Alteration of Protein Synthesis in Cartilage by a Synthetic Double-Stranded Polyribonucleotide.
M. Clair and L. Wadell (1971)
Journal of Dental Research 50, 1072-1079
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Increased Protocollagen Proline Hydroxylase Activity in Sclerodermatous Skin.
H. R. Keiser, H. D. Stein, and A. Sjoerdsma (1971)
Arch Dermatol 104, 57-60
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Elevation of Aortic Proline Hydroxylase: A Biochemical Defect in Experimental Arteriosclerosis.
G. C. Fuller and R. O. Langner (1970)
Science 168, 987-989
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The Intracellular Biosynthesis of Collagen: Some Possible Implications for Diseases of Bone and Other Connective Tissues.
D. J. Prockop (1969)
Arch Intern Med 124, 563-570
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