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Science 18 August 1967:
Vol. 157. no. 3790, pp. 831 - 833
DOI: 10.1126/science.157.3790.831
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Articles

Athens Variant of Glucose-6-Phosphate Dehydrogenase

George Stamatoyannopoulos 1, Akira Yoshida 1, Chr. Bacopoulos 2, and Arno G. Motulksy 3

1 Department of Medicine, Division of Medical Genetics, University of Washington, Seattle 98105
2 Aglaia Kyriakou Children's Hospital Goudi, Athens, Greece
3 Departments of Medicine and Genetics, University of Washington

A variant of glucose-6-phosphate dehydrogenase (G6PD), characterized by slower than normal electrophoretic migration and associated with mild deficiency of G6PD in the red cells, was detected in two unrelated Greek males. Electrophoretic, chromatographic, and enzymologic study indicated that the new mutant is structurally different from normal G6PD (B+) and from the Mediterranean variant associated with red-cell enzyme deficiency (B-). Convincing electrophoretic separation of the new variant from the normal B+ and the Mediterranean B- enzymes was achieved only by detailed electrophoretic study in different buffer systems and conditions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chloramphenicol-Induced Hemolysis in Caucasian Glucose-6-Phosphate Dehydrogenase Deficiency.
R. P. MCCAFFREY, C. H. HALSTED, M. F. ABDEL WAHAB, and R. P. ROBERTSON (1971)
Ann Intern Med 74, 722-726
   Abstract »    PDF »
Variants of Glucose 6-Phosphate Dehydrogenase.
I. H. PORTER (1968)
Ann Intern Med 68, 250-252
   Abstract »    PDF »


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