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Science 11 August 1967:
Vol. 157. no. 3789, pp. 703 - 705
DOI: 10.1126/science.157.3789.703
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Articles

Oncogenicity by DNA Tumor Viruses: Enhancement after Ultraviolet and Cobalt-60 Radiations

V. Defendi 1 and F. Jensen 1

1 Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania

Simian virus-40, polyoma, and LLE46 virus preparations were treated with ultraviolet or gamma radiations (cobalt-60) in a frozen state. Infectivity and induction of complement-fixing antigen and DNA synthesis declined as a logarithmic function of dose, the latter two properties being more resistant than infectivity to radiation by a factor of 2 to 5. Oncogenicity of all three viruses did not decrease with progressive amounts of both types of irradiation, but actually increased in absolute and relative terms (per infectious unit), even at the maximum dose of irradiation used (24,000 ergs per square millimeter per minute and 2.7 x 106 rads).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
T-antigen-associated Proteins Induced by SV40 Transformation.
J. A. Melero, D. S. Greenspan, and R. B. Carroll (1980)
Cold Spring Harb Symp Quant Biol 44, 201-210
   Abstract »    PDF »
Demonstration of the Oncogenic Potential of Herpes Simplex Viruses and Human Cytomegalovirus.
F. Rapp and J.-L. H. Li (1974)
Cold Spring Harb Symp Quant Biol 39, 747-763
   Abstract »    PDF »


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