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Science 28 July 1967:
Vol. 157. no. 3787, pp. 439 - 440
DOI: 10.1126/science.157.3787.439
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Articles

Langerhans Cells: Uptake of Tritiated Thymidine

L. Giacometti 1 and W. Montagna 1

1 Department of Cutaneous Biology, Oregon Regional Primate Research Center, Beaverton 97005

After irradiation of the skin of the rhesus monkey with ultraviolet light, there is temporary suppression of the proliferating activity of the epidermal cells, followed by some hyperplasia and a striking increase in synthesis of DNA by Langerhans cells. Since Langerhans cells can proliferate, they can no longer be considered to be worn-out melanocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network.
L. Chorro, A. Sarde, M. Li, K. J. Woollard, P. Chambon, B. Malissen, A. Kissenpfennig, J.-B. Barbaroux, R. Groves, and F. Geissmann (2009)
J. Exp. Med. 206, 3089-3100
   Abstract »    Full Text »    PDF »
Cutaneous Syndromes of Non-X Histiocytosis: A Review of the Macrophage-Histiocyte Diseases of the Skin.
R. K. Winkelmann (1981)
Arch Dermatol 117, 667-672
   Abstract »    PDF »
Selective Uptake of Contact Allergens by the Langerhans Cell.
W. B. Shelley and L. Juhlin (1977)
Arch Dermatol 113, 187-192
   Abstract »    PDF »


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