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Science 21 July 1967:
Vol. 157. no. 3786, pp. 318 - 319
DOI: 10.1126/science.157.3786.318
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Articles

Release of Slow-Reacting Substance of Anaphylaxis in the Rat: Polymorphonuclear Leukocyte

Robert P. Orange 1, Martin D. Valentine 1, and K. Frank Austen 1

1 Harvard Medical School, Robert B. Brigham Hospital, Boston, Massachusetts 02120

The antigen-induced release of slow-reacting substance of anaphylaxis was studied in rats previously treated with different biological and pharmacological agents to deplete these animals of specific cellular elements. The polymorphonuclear leukocyte appears necessary as a crucial cell type for optimum release of the slow-reacting substance of anaphylaxis, whereas the mast cell and lymphocyte are not required.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)