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Science 14 July 1967:
Vol. 157. no. 3785, pp. 210 - 211
DOI: 10.1126/science.157.3785.210

Articles

Enterogastrone Inhibits Eating by Fasted Mice

Andrew V. Schally 1, Tommie W. Redding 1, Harold W. Lucien 1, and Joe Meyer 2

1 Endocrine and Polypeptide Laboratories, Veterans Administration Hospital, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana
2 Veterans Administration Central Office, Washington, D.C.

In mice fasted for 17 hours, administration of enterogastrone purified from hog duodenum reduced the food intake. This effect was greatest during the first 30 minutes, but the cumulative reduction continued for at least 4 hours. Other peptides prepared from hog duodenum or colon, as well as glucagon, secretin, glucose, and bovine serum albumin, were ineffective.


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