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Science 7 July 1967:
Vol. 157. no. 3784, pp. 84 - 85
DOI: 10.1126/science.157.3784.84
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Articles

Structural Basis for the Inhibition of Protein Biosynthesis: Mode of Action of Tubulosine

Arthur P. Grollman 1

1 Department of Medicine, Albert Einstein College of Medicine, New York 10461

A structural model for the inhibition of protein biosynthesis was previously formulated on the basis of a topochemical analogy between the ipecac alkaloids and the glutarimide antibiotics. The structure of tubulosine satisfies the requirements of this model. The prediction that such a compound would exhibit amebicidal activity and act by selectively inhibiting the transfer reaction in protein biosynthesis is confirmed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Metabolism and Function of Alkaloids in Plants.
T. Robinson (1974)
Science 184, 430-435
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Science. ISSN 0036-8075 (print), 1095-9203 (online)