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Science 7 July 1967:
Vol. 157. no. 3784, pp. 75 - 76
DOI: 10.1126/science.157.3784.75
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Articles

Benzpyrene Hydroxylase Induction by Polycyclic Hydrocarbons in Hamster Embryonic Cells Grown in vitro

L. J. Alfred 1 and H. V. Gelboin 1

1 National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Treatment of hamster embryonic cells with 1,2-benzanthracene for 4 to 48 hours induced a three- to tenfold increase in the activity of benzpyrene hydroxylase. That the increase in enzyme activity was completely prevented by puromycin suggested an induction of enzyme synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]anthracene.
J. P. Whitlock Jr., H. L. Cooper, and H. V. Gelboin (1972)
Science 177, 618-619
   Abstract »    PDF »
Induction of Benzo[agr]pyrene Hydroxylase in Human Skin.
W. Levin, A. H. Conney, A. P. Alvares, I. Merkatz, and A. Kappas (1972)
Science 176, 419-420
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Microsomal Hydroxylase Induction in Liver Cell Culture by Phenobarbital, Polycyclic Hydrocarbons, and p,p'-DDT.
J. E. Gielen and D. W. Nebert (1971)
Science 172, 167-169
   Abstract »    PDF »
Dimethylbenzanthracene Tumorigenesis and Aryl Hydrocarbon Hydroxylase in Mouse Skin: Inhibition by 7,8-Benzoflavone.
H. V. Gelboin, F. Wiebel, and L. Diamond (1970)
Science 170, 169-171
   Abstract »    PDF »
Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase.
L. Diamond and H. V. Gelboin (1969)
Science 166, 1023-1025
   Abstract »    PDF »


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