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Science 30 June 1967:
Vol. 156. no. 3783, pp. 1750 - 1752
DOI: 10.1126/science.156.3783.1750
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Articles

Adenyl Cyclase Activity in Rat Pineal Gland: Effects of Chronic Denervation and Norepinephrine

Benjamin Weiss 1 and Erminio Costa 1

1 Departments of Pharmacology and Neurology, College of Physicians and Surgeons of Columbia University, New York 10032

Adenyl cyclase activity in the pineal gland of rats was determined by measuring the rate of formation of radioactive cyclic 3',5'-adenosine monophosphate from 14C-labeled adenosine triphosphate. Norepinephrine added in vitro to pineal homogenates enhanced this activity, while denervation of the pineal gland by superior cervical ganglionectomy did not significantly reduce it. The enzyme in these denervated glands was more responsive to the stimulatory effects of norepinephrine.


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