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Science 30 June 1967:
Vol. 156. no. 3783, pp. 1742 - 1744
DOI: 10.1126/science.156.3783.1742
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Articles

Hereditary Renal Disease in a Mutant Strain of Rats

Bismarck B. Lozzio 1, Amoz I. Chernoff 1, Emilio R. Machado 2, and Carmen B. Lozzio 3

1 University of Tennessee, Memorial Research Center, Knoxville
2 Instituto de Gastroenterología Institutos Nacionales de la Salud Haedo, Buenos Aires, Argentina
3 University of Tennessee

Disease of the kidney developed in breeding stock of Gunn rats. The renal lesion is the result of a new mutation. The genetic defect is inherited as an autosomal dominant trait and is apparently lethal in the homozygous condition. The abnormality manifests itself as a congenital hydronephrosis with related cystic changes in the kidney.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)