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Science 2 June 1967:
Vol. 156. no. 3779, pp. 1244 - 1245
DOI: 10.1126/science.156.3779.1244
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Articles

Lactones as Inhibitors of the Fibrinolytic System

Wilhelm Auerswald 1 and Walter Doleschel 1

1 Department of Physiology, Vienna University Medical School, Austria

Caprolactone, valerolactone, and butyrolactone inhibit proteolytic and fibrinolytic activities of human plasmin. In very low concentrations, they also inhibit activation of plasminogen through plasmin-streptokinase activator and human urokinase. The degree of inhibitory potency depends upon the number of carbon atoms in the lactone.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)