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Science 2 June 1967:
Vol. 156. no. 3779, pp. 1240 - 1241
DOI: 10.1126/science.156.3779.1240
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Articles

Transport and Phosphorylation as Factors in the Antitumor Action of Cytosine Arabinoside

David Kessel 1, Thomas C. Hall 1, and Isidore Wodinsky 2

1 Children's Cancer Research Foundation, Boston, Massachusetts
2 Arthur D. Little, Inc., Cambridge, Massachusetts

Survival of mice bearing different transplantable leukemias and treated with cytosine arabinoside was compared with uptake and subsequent phosphorylation of the drug in vitro. Capacity for nucleotide formation was correlated with response and is apparently an important determinant of drug sensitivity. Drug uptake, although apparently mediated, was similar in all cell lines.


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Mol. Cancer Ther. 1, 371-376
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Science. ISSN 0036-8075 (print), 1095-9203 (online)