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Science 19 May 1967:
Vol. 156. no. 3777, pp. 951 - 954
DOI: 10.1126/science.156.3777.951
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Articles

Drug-Induced Tolerance for Skin Allografts across the H-2 Barrier in Adult Mice

Georg L. Floersheim 1

1 Pharmacological Institute, University of Basel, Basel, Switzerland

Mice treated with methylhydrazine derivatives for 3 to 4 weeks before the transplantation showed markedly prolonged survival times for allogeneic skin grafts differing at the H-2 histocompatibility locus. Presumably permanent tolerance was induced in about 20 to 30 percent of the mice when the drug treatment was combined with a single injection of additional donor antigen. The tolerance persists without further drug treatment and is specific for donor tissue.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antiserum to Lymphocytes and Procarbazine Compared as Immunosuppressants in Mice.
P. B. Stewart and V. Cohen (1969)
Science 164, 1082-1083
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