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Science 28 April 1967:
Vol. 156. no. 3774, pp. 519 - 520
DOI: 10.1126/science.156.3774.519
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Articles

Progesterone: Its Possible Role in the Biosynthesis of Cardenolides in Digitalis lanata

E. Caspi 1 and D. O. Lewis 1

1 Worcester Foundation for Experimental Biology, Shrewsbury, Massachutsetts

The incorporation of progestrone-7alpha-3H and pregnenolone-7alpha-3H into digitoxigenin, gitoxigenin, and digoxigenin in isolated, surviving leaves of Digitalis lanata was demonstrated. In addition, the conversion of pregnenolone to progesterone in the same system was proved. The results tend to indicate that progesterone is as good a precursor of cardenolides as pregnenolone It is suggested that the biosynthesis of cardenolides might proceed through the intermediacy of progesterone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Crystal Structure of Progesterone 5{beta}-Reductase from Digitalis lanata Defines a Novel Class of Short Chain Dehydrogenases/Reductases.
A. Thorn, C. Egerer-Sieber, C. M. Jager, V. Herl, F. Muller-Uri, W. Kreis, and Y. A. Muller (2008)
J. Biol. Chem. 283, 17260-17269
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Science. ISSN 0036-8075 (print), 1095-9203 (online)