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Science 17 March 1967:
Vol. 155. no. 3768, pp. 1417 - 1419
DOI: 10.1126/science.155.3768.1417
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Articles

Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide

Maimon M. Cohen 1, Michelle J. Marinello 1, and Nathan Back 2

1 Department of Pediatrics, School of Medicine, State University of New York, and Buffalo Children's Hospital, Buffalo
2 Department of Biochemical Pharmacology, School of Pharmacy, State University of New York

Addition of lysergic acid diethylamide to cultured human leukocytes resulted in a marked increase of chromosomal abnormalities. The distribution of chromosome breaks deviated significantly from random, with an accumulation of aberrations in chromosome No. 1. Cytogenetic investigation of a patient extensively treated with this drug over a 4-year period for paranoid schizophrenia showed a similar increase in chromosomal damage.


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