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Science 10 March 1967:
Vol. 155. no. 3767, pp. 1259 - 1261
DOI: 10.1126/science.155.3767.1259-a
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Articles

Collagen-Coated Cellulose Sponge: Three-Dimensional Matrix for Tissue Culture of Walker Tumor 256

Joseph Leighton 1, Gerald Justh 1, Martha Esper 1, and Richard L. Kronenthal 2

1 Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
2 Research Division, Ethicon, Inc., Somerville, New Jersey

Three-dimensional growth of large populations of cells in vitro has been observed in the interstices of a matrix consisting of collagen-coated cellu lose sponge. The growth of Walker tumor 256 in this composite matrix is com pared with that found in a matrix composed of either cellulose sponge alone or collagen sponge alone. The composite matrix is superior to either one. Collagen coated cellulose sponge may provide a simple tool for the study of social interaction of cells in the formation of organized elementary tissue structures.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)