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Science 10 March 1967:
Vol. 155. no. 3767, pp. 1254 - 1257
DOI: 10.1126/science.155.3767.1254
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Articles

Ribosomes: Effect of Interferon on Their Interacton with Rapidly Labeled Cellular and Viral RNA's

William A. Carter 1 and Hilton B. Levy 1

1 National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014

Rapidly labeled RNA of mouse L cells and labeled RNA of Mengo virus, unlike cellular RNA labeled under steady-state conditions, form detectable complexes with L-cell ribosomes. These ribosome-RNA complexes formed in vitro appear analogous to those assembled during polysome formation in vivo. When ribosomes are prepared from L cells exposed to homologous interferon, their capacity to associate with cell messenger is preserved, while their ability to interact with viral RNA is markedly reduced. The ribosomes from cells exposed to interferon are thus altered selectively to permit only certain messages to be bound and translated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interferon Action: Inhibition of Vesicular Stomatitis Virus RNA Synthesis Induced by Virion-Bound Polymerase.
P. I. Marcus, D. L. Engelhardt, J. M. Hunt, and M. J. Sekellick (1971)
Science 174, 593-598
   Abstract »    PDF »
Double-Stranded RNAs (Poly I:C) in the Prevention of Viral Infections.
M. R. Hilleman (1970)
Arch Intern Med 126, 109-124
   Abstract »    PDF »


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