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Science 3 March 1967:
Vol. 155. no. 3766, pp. 1120 - 1121
DOI: 10.1126/science.155.3766.1120
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Articles

Mammalian X-Chromosomes: Change in Patterns of DNA Replication during Embryogenesis

Richard N. Hill 1 and Jorge J. Yunis 2

1 Genetics Department, University of Minnesota, Minneapolis 55455
2 Medical Genetics Laboratory, University of Minnesota Medical School, Minneapolis 55455

One arm of both X-chromosomes in female eight-cell embryos of the golden hamster replicates late in the period of DNA synthesis. Midgestation embryos and adult fibroblasts show an increase in late-replicating DNA. Here, one X-chromosome is labeled in one arm; the other is labeled throughout.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)