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Science 3 March 1967:
Vol. 155. no. 3766, pp. 1116 - 1118
DOI: 10.1126/science.155.3766.1116
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Articles

Heme and Globin Synthesis Control: Observations in vivo in Beta Thalassemia

Martha Kreimer-Birnbaum 1 and Robin M. Bannerman 1

1 Department of Medicine, State University of New York at Buffalo, and Buffalo General Hospital, 100 High Street, Buffalo 14203

After administration of glycine-2-14C to a patient with thalassemia, the specific activities of heme and globin of F hemoglobin were consistently higher than those of hemoglobin A. After reaching a maximum, the ratio of the specific activity of heme to that of globin remained constant within each hemoglobin. Explanations considered include dilution by preformed subunits, differential turnover of hemoglobins, and possibly more than one heme-synthesizing pool.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)