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Science 24 February 1967:
Vol. 155. no. 3765, pp. 1033 - 1035
DOI: 10.1126/science.155.3765.1033
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Articles

Phenylketonuria: Enduring Behavioral Deficits in Phenylketonuric Rats

Robert L. Schalock 1 and F. D. Klopfer 2

1 Mental Health Research Institute, Fort Steilacoom, Washington 98494
2 Comparative Behavior Laboratory, Washington State University, Pullman

The behavioral deficit in rats made "phenylketonuric" by ingestion of L-phenylalanine was evaluated 23 to 65 days following cessation of treatment. Animals treated from birth to 60 days showed significant deficit on reasoning and discrimination learning tests but not on discrimination reversal sets. Animals treated from 30 to 60 days showed significant deficit only on the reasoning test.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Aminoacidemias: Effects on Maze Performance and Cerebral Serotonin.
C. M. McKean, S. M. Schanberg, and N. J. Giarman (1967)
Science 157, 213-215
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Science. ISSN 0036-8075 (print), 1095-9203 (online)