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Science 10 February 1967:
Vol. 155. no. 3763, pp. 716 - 718
DOI: 10.1126/science.155.3763.716
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Articles

Conditioning with Delayed Vitamin Injections

J. Garcia 1, F. R. Ervin 1, C. H. Yorke 1, and R. A. Koelling 1

1 Department of Psychiatry, Harvard Medical School, and Neurological Service, Department of Surgery, Massachusetts General Hospital, Boston

Rats deficient in thiamine were allowed to drink saccharin-fla vored water. They were then given an injection of thiamine which caused their intake of the nonnutritive fluid to increase. Delay of the intramuscular injection up to 30 minutes had no effect upon the acquisition of this condi tioning. Presumably, this delay reflects specialization in the central integrative mechanisms which serve these afferent modalities.


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