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Science 3 February 1967:
Vol. 155. no. 3762, pp. 593 - 595
DOI: 10.1126/science.155.3762.593
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Articles

Antiandrogen Implanted in Brain Stimulates Male Reproductive System

George J. Bloch 1 and Julian M. Davidson 1

1 Department of Physiology, Stanford University School of Medicine, Stanford, California

Chronic intrahypothalanic implantation of cyproterone, an antiandrogen, in male rats resulted in specific stimulation of testes, seminal vesicles, and prostates. Implantation of cholesterol-filled or empty tubes in the median eminence in controls was ineffective. We conclude that decreases in the amount of testosterone reaching specific receptors in the median eminence or in nearby regions activate a mechanism that produces increased gonadotropin secretion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Androgen Accumulation and Binding to Macromolecules in Seminal Vesicles: Inhibition by Cyproterone.
J. M. Stern and A. J. Eisenfeld (1969)
Science 166, 233-235
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Science. ISSN 0036-8075 (print), 1095-9203 (online)