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Science 20 January 1967:
Vol. 155. no. 3760, pp. 337 - 338
DOI: 10.1126/science.155.3760.337
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Articles

Passive Transfer of Tuberculin Reactivity in Vitro

Philip Fireman 1, Mary Boesman 1, Zaky H. Haddad 1, and David Gitlin 1

1 Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213

A factor capable of effecting passive transfer in vivo of delayed hypersensitivity to tuberculin to recipients that are tuberculin negative was isolated from the dialyzate of disrupted leukocytes of tuberculin-positive individuals. After this factor was incubated with cultures of peripheral leukocytes from tuberculin-negative individuals, the addition of purified protein derivative of tubercle bacilli resulted in leukocyte stimulation similar to that observed after addition of purified protein derivative to leukocytes from tuberculin-positive individuals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transfer Factor from Guinea Pigs Sensitive to Dinitrochlorobenzene: Absence of Superantigen Properties.
D. R. Burger, R. M. Vetto, and A. Malley (1972)
Science 175, 1473-1475
   Abstract »    PDF »
Delayed Hypersensitivity in Man: A Correlate in vitro and Transfer by an RNA Extract.
D. E. Thor (1967)
Science 157, 1567-1569
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)