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Science 13 January 1967:
Vol. 155. no. 3759, pp. 210 - 211
DOI: 10.1126/science.155.3759.210

Articles

Diphenamid Metabolism in Plants

Charles Heidelberger 1 and P. T. Iype 1

1 McArdle Laboratory for Cancer Research, University of Wisconsin, Madison

Diphenamid, a herbicide, is metabolized to N-methyl 2,2-diphenylacetamide and 2,2-diphenylacetamide by the common soil fungi Trichoderma viride and Aspergillus candidus within 48 hours. The two metabolites are more toxic than diphenamid to both tomato and barnyard-grass seedlings under sterile conditions. This finding indicates that the phytotoxic moiety is not diphenamid but one of its metabolites-probably the N-methyl derivative.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)