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Science 30 December 1966:
Vol. 154. no. 3757, pp. 1667 - 1668
DOI: 10.1126/science.154.3757.1667
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Articles

Naturally Occurring Antimetabolite Antibiotic Related to Biotin

L. J. Hanka 1, M. E. Bergey 1, and R. B. Kelly 1

1 Research Laboratories, Upjohn Company, Kalamazoo, Michigan

A crystalline antibiotic produced by Streptomyces lydicus has been isolated and shown to be the hitherto unknown agra-dehydrobiotin (I). This is active against a variety of grampositive and gram-negative bacteria and fungi. Its antimicrobial activity is reversed by the presence of biotin in growth media.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)