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Science 23 December 1966:
Vol. 154. no. 3756, pp. 1574 - 1575
DOI: 10.1126/science.154.3756.1574
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Articles

Brain Sensitivity to Alcohol in Inbred Mouse Strains

Ryoko Kakihana 1, David R. Brown 2, Gerald E. McClearn 3, and Irving R. Tabershaw 2

1 Department of Psychiatry, Stanford University School of Medicine, Palo Alto, California
2 School of Public Health, University of California, Berkeley
3 Department of Psychology, University of Colorado, Boulder

The voluntary selection of aqueous ethanol in preference to water has been studied in a number of animal species. A pharmacological phenomenon observed in all species, including humans, is depression of the central nervous system which eventually leads to "sleep." The sleeping time at a given concentration of alcohol in the brain depends on strain sensitivity.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)