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Science 25 November 1966:
Vol. 154. no. 3752, pp. 1044 - 1046
DOI: 10.1126/science.154.3752.1044
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Articles

Multiple Sclerosis: Correlaion between lImmunoglobulin-G in Cerebrospinal Fluid and Brain

Wallace W. Tourtellotte 1 and Julius A. Parker 1

1 Neurology Research Laboratory and Multiple Sclerosis Clinic, University of Michigan Medical Center, Ann Arbor

There is a positive correlation between the concentration of immunoglobulin-G in plaques of demyelination due to multiple sclerosis (as well as in white matter of normal appearance) and the concentration of this globulin in the cerebrospinal fluid. The tentative conclusion drawn from these results was that, in patients with multiple sclerosis, the increase in immuno-globulin-G in the cerebrospinal fluid is a reflection of an excess of this globulin in the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lipids in Cerebrospinal Fluid: XII. In Multiple Sclerosis and Retrobulbar Neuritis.
W. W. Tourtellotte and A. F. Haerer (1969)
Arch Neurol 20, 605-615
   Abstract »    PDF »
CSF Immunoglobulins in Multiple Sclerosis and Other Neurologic Diseases: Measurement by Electroimmunodiffusion.
S. A. Schneck and H. N. Claman (1969)
Arch Neurol 20, 132-139
   Abstract »    PDF »
An Unusual IgG Globulin: Frequency of Occurrence in Cerebrospinal Fluid in Multiple Sclerosis.
C. F. C. MacPherson and J. B. R. Cosgrove (1968)
Arch Neurol 19, 503-509
   Abstract »    PDF »
Origin of Cerebrospinal Fluid Gamma Globulin in Subacute Sclerosing Leukoencephalitis.
R. W. P. Cutler, G. V. Watters, J. P. Hammerstad, and E. Merler (1967)
Arch Neurol 17, 620-628
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)