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Science 25 November 1966:
Vol. 154. no. 3752, pp. 1041 - 1043
DOI: 10.1126/science.154.3752.1041

Articles

Genetically Determined Antigen of the Ne Subgroup of Gamma-Globulin: Detection by Precipitin Analysis

H. G. Kunkel 1, W. J. Yount 1, and S. D. Litwin 1

1 Rockefeller University, New York

A genetic antigen, Gm(n), has been described for the Ne subgroup of gamma-globulin previously devoid of Gm factors. It was detected by precipitin tests with a primate antiserum to Ne-type heavy chains. A relation to the Gm(b) antigens of the Vi subgroup and the Gm(f) and Gm(y) antigens of the We subgroup was apparent. The availablity of genetic antigens for the heavy chains of three subgroups of gamma-globulin with varying relationships in different populations offers an approach to the mapping of the genes concerned.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Two Types Of Lambda Polypeptide Chains In Human Immunoglobulins.
D. Ein and J. L. Fahey (1967)
Science 156, 947-948
   Abstract »    PDF »
Genetic Markers of the Heavy Chain Subgroups of Human {gamma}G Globulin.
J. B. Natvig, H. G. Kunkel, and S. D. Litwin (1967)
Cold Spring Harb Symp Quant Biol 32, 173-180
   Abstract »    PDF »



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