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Science 18 November 1966:
Vol. 154. no. 3751, pp. 911 - 913
DOI: 10.1126/science.154.3751.911-a
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Articles

Nucleotide Formation as a Determinant of 5-Fluorouracil Response in Mouse Leukemias

David Kessed 1, Thomas C. Hall 1, and Isidore Wodinsky 2

1 Children's Cancer Research Foundation, Boston, Massachusetts
2 Arthuer D. Little, Inc., Cambridge, Massachusetts

Survival of mice bearing different transplantable leukemias and treated with 5-fluorouracil was compared with accumulation of drug nucleotides in vitro. There was significant correlation,suggesting that cellular capacity for conversion of the drug to nucleotides is a major determinant of inherent drug sensitivity of these leukemias.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fluorouracil: Mechanism of Action in Human Skin and Actinic Keratoses: I. Effect on DNA Synthesis in Vivo.
W. H. Eaglstein, G. D. Weinstein, and P. Frost (1970)
Arch Dermatol 101, 132-139
   Abstract »    PDF »
Transport and Phosphorylation as Factors in the Antitumor Action of Cytosine Arabinoside.
D. Kessel, T. C. Hall, and I. Wodinsky (1967)
Science 156, 1240-1241
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)