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Science 18 November 1966:
Vol. 154. no. 3751, pp. 901 - 903
DOI: 10.1126/science.154.3751.901
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Articles

Paraproteinemia and Reticulum Cell Sarcoma in an Inbred Mouse Strain

Harold J. Wanebo 1, Walter M. Gallmeier 1, Edward A. Boyse 1, and Lloyd J. Old 1

1 Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021

Mice of the inbred SJL/J strain have a high incidence of a proliferative disease affecting several cell types, including reticulum cells and plasma cells, which is frequently accompanied by ggr1 and ggr2 paraproteinemia. In only some instances can seriallytransplantable lines of neoplastic cells be obtained; these are reticulum cell sarcomas. Mice with transplanted reticulum cell e arcomas do not have paraproteinemia and may develop profound hypogammaglobulinemia. The disease may be viewed as an abnormal proliferation of reticulum cells which differentiate into plasma cells with consequent paraproteinemia; the subsequent emergence of transplantable reticulum cell sarcoma appears as an end stage in which this capacity to differentiate is lost.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Anaplastic, Plasmablastic, and Plasmacytic Plasmacytomas of Mice: Relationships to Human Plasma Cell Neoplasms and Late-Stage Differentiation of Normal B Cells.
C.-F. Qi, J. X. Zhou, C. H. Lee, Z. Naghashfar, S. Xiang, A. L. Kovalchuk, T. N. Fredrickson, J. W. Hartley, D. C. Roopenian, W. F. Davidson, et al. (2007)
Cancer Res. 67, 2439-2447
   Abstract »    Full Text »    PDF »
Retrovirus-Induced Lymphoproliferation as a Model for Developing Diagnostic Criteria for Malignant Lymphoma in Mice.
T. N. Fredrickson, Yao Tang, S. K. Chattopadhyay, H. C. Morse III, and J. W. Hartley (1993)
Toxicol Pathol 21, 219-228
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