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Science 4 November 1966:
Vol. 154. no. 3749, pp. 665 - 667
DOI: 10.1126/science.154.3749.665
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Articles

Enhanced Growth of Human Embryonic Cells Infected with Adenovirus 12

I. V. Sultanian 1 and G. Freeman 1

1 Department of Medical Sciences, Stanford Research Institute, Menlo Park, California 94025

Fibroblast-like cells from human embryonic lung were infected with adenovirus type 12, and they survived as an established line, with the characteristics of "transformation" following considerable cellular killing. Inclusion bodies disappeared and cells became resistant to reinfection with type 12 virus as they grew in thick multilayered strands, and giant and syncytial cells became commonplace. An induced new cell antigen demonstrable by complement-fixation and fluorescent-antibody studies persisted for at least 20 culture passages after infection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Contaminating Hamster Cells.
G. Freeman (1968)
Science 161, 1201
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Science. ISSN 0036-8075 (print), 1095-9203 (online)