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Science 21 October 1966:
Vol. 154. no. 3747, pp. 402 - 403
DOI: 10.1126/science.154.3747.402
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Articles

Pituitary Tumors in Mice after Prolonged Feeding of Synthetic Progestins

W. E. Poel 1

1 University of Pittsburgh, Pittsburgh, Pennsylvania

An enhanced development of pituitary tumors was observed in virgin female mice of the C57 Leaden strain following repeated oral administration of synthetic progestins. This finding appears to parallel the co-carcinogenic enhancement of mammary tumor development elicited in C3H mice treated repeatedly with progesterone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sex Steroid-Dependent and -Independent Action of Hydroxysteroid (17{beta}) Dehydrogenase 2: Evidence from Transgenic Female Mice.
Z. Shen, T. Saloniemi, A. Ronnblad, P. Jarvensivu, P. Pakarinen, and M. Poutanen (2009)
Endocrinology 150, 4941-4949
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Science. ISSN 0036-8075 (print), 1095-9203 (online)