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Science 21 October 1966:
Vol. 154. no. 3747, pp. 396 - 398
DOI: 10.1126/science.154.3747.396
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Articles

Sleep: Suppression of Rapid Eye Movement Phase in the Cat after Electroconvulsive Shock

Harry B. Cohen 1 and William C. Dement 1

1 Department of Psychiatry, Stanford University School of Medicine, Palo Alto, California, and Veterans Administration Hospital, Menlo Park, California

Electroconvulsive shock, administered for 5 to 7 days, reduced the daily rapid eye movement sleep time of seven cats to as little as 28 percent of base line levels. After day 4, eye movements during periods of cortical activation without tonic electromyographic activity were greatlyreduced. Although partially deprived of rapid eye movements for as long as 7 days, the cats showed no compensatory rise in rapid eye movement time during the recovery period, but controls equally deprived gave significant rebounds. Rapid eye movement time of anesthetized cats was not affected by current that usually produces con vulsions; it was lowered in animals convulsed with metrazol, but the same dosage of this drug, administered so as to avoid convulsions, had little eflect.It appears that some aspect of the convulsion is responsible for lowering the rapid eye movement time.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Relation between REM Sleep and Intracranial Self-Stimulation.
S. S. Steiner and S. J. Ellman (1972)
Science 177, 1122-1124
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Sleep: The Effect of Electroconvulsive Shock in Cats Deprived of REM Sleep.
H. B. Cohen, R. F. Duncan II, and W. C. Dement (1967)
Science 156, 1646-1648
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Sleep and Depression: A Follow-Up Study.
J. Mendels and D. R. Hawkins (1967)
Arch Gen Psychiatry 16, 536-542
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Sleep and Electroconvulsive Therapy.
V. Zarcone, G. Gulevich, and W. Dement (1967)
Arch Gen Psychiatry 16, 567-573
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