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Science 30 September 1966:
Vol. 153. no. 3744, pp. 1668 - 1670
DOI: 10.1126/science.153.3744.1668
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Articles

Aminooxyacetic Acid: Interactions with Gamma-Aminobutyric Acid and the Blood-Brain Barrier

Morris A. Fisher 1, Duane Q. Hagen 1, and Robert B. Colvin 1

1 Psychiatric Research Department, Massachusetts General Hospital, Boston

The hypothesis that the administration of aminooxyacetic acid, a competitive inhibitor of aminobutyrate aminotransferase, might allow gamma-aminobutyric acid to cross the blood-brain barrier was tested by analyzing the brains of rats for this compound after intraperitoneal injection of aminooxyacetic acid, or a mixture of both acids, and by observing behavioral and physiological changes in cats after similar drug administrations. The results do not support the postulate that gamma-aminobutyric acid enters the brain more readily after administration of aminooxyacetic acid.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)