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Science 30 September 1966:
Vol. 153. no. 3744, pp. 1650 - 1652
DOI: 10.1126/science.153.3744.1650
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Articles

Urea Synthesis in the Lungfish: Relative Importance of Purine and Ornithine Cycle Pathways

R. P. Forster 1 and Leon Goldstein 2

1 Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755
2 Department of Physiology, Harvard Medical School, Boston, Massachusetts

The relative importance of the purine pathway (uricolysis) and the ornithine cycle as routes for urea synthesis was assessed in isolated liver preparations from the African lungfish Protopterus dolloi. Incorporation of C14-labeled precursors into urea was used for comparison. Both pathways are present in the lungfish, but the ornithine cycle is quantitatively more important.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)