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Science 23 September 1966:
Vol. 153. no. 3743, pp. 1547 - 1549
DOI: 10.1126/science.153.3743.1547
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Articles

Long Temporal Gradient of Retrograde Amnesia for a Well-Discriminated Stimulus

Rudolf Kopp 1, Zdenek Bohdanecky 1, and Murray E. Jarvik 1

1 Department of Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461

This experiment tested the general validity of recent findings that retrograde amnesia can be produced by electroconvulsive shock only if the shock is administered within 10 to 30 seconds after the learning trial. Precautions were taken to avoid confusion of other shock effects with retrograde amnesia. A temporal gradient of elec- troconvulsive shock-produced retrograde amnesia, extending up to at least 1 hour, for a well-discriminated stimulus, was demonstrated in mice in a one-trial learning passive avoidance situation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Retrograde Amnesia Gradients: Effects of Direct Cortical Stimulation.
P. E. Gold, J. Macri, and J. L. McGaugh (1973)
Science 179, 1343-1345
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Electroshock Effects on Brain Protein Synthesis: Relation to Brain Seizures and Retrograde Amnesia.
C. W. Cotman, G. Banker, S. F. Zornetzer, and J. L. McGaugh (1971)
Science 173, 454-456
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Retrograde Amnesia Produced by Electroconvulsive Shock after Reactivation of a Consolidated Memory Trace.
J. R. Misanin, R. R. Miller, and D. J. Lewis (1968)
Science 160, 554-555
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Reinforcement Magnitude as a Determinant of Performance Decrement after Electroconvulsive Shock.
O. S. Ray and L. W. Bivens (1968)
Science 160, 330-332
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Amnesic Effects of Small Bilateral Brain Puncture in the Mouse.
M. Bohdanecka, Z. Bohdanecky, and M. E. Jarvik (1967)
Science 157, 334-336
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