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Science 9 September 1966:
Vol. 153. no. 3741, pp. 1257 - 1259
DOI: 10.1126/science.153.3741.1257
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Articles

Antibody Molecules: Discontinuous Heterogeneity of Heavy Chains

O. A. Roholt 1 and D. Pressman 1

1 Department of Biochemistry Research, New York State Department of Health, Roswell Park Memorial Institute, Buffalo

The heavy polypeptide chains of antibody ( and of ggrG-immnunoglobulin) molecules show discrete bands on disc electrophoresis. The same bands are present for chains from antibodies of the same or diverse specificities. Individual bands are of different intensities for chains from the different rabbits tested even if the antibodies are directed against the same hapten. The bands appear to represent classes of heterogeneous H-chains of the same size having discrete differences in mizobilities with respect to a single charge difference.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)