Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 September 1966:
Vol. 153. no. 3740, pp. 1130 - 1133
DOI: 10.1126/science.153.3740.1130
Prev | Table of Contents | Next

Articles

Methylene-C14-Dioxyphenyl Compounds: Metabolism in Relation to Their Synergistic Action

John E. Casida 1, Judith L. Engel 1, Essac G. Essac 1, Francis X. Kamienski 1, and Shozo Kuwatsuka 1

1 Division of Entomology, University of California, Berkeley

The methylene-C14 group is hydroxylated yielding formate-C14 in the microsome-reduced nicotinamide-adenine dinucleotide phosphate system in vitro and yielding expired C14O2, in living mice and houseflies. Methylenedioxyphenyl compounds apparently serve as alternate substrates for this enzymatic hydroxylation system of microsomes, and thus reduce the rate of metabolism and prolong the action of certain drugs and insecticide chemicals.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)