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Science 2 September 1966:
Vol. 153. no. 3740, pp. 1127 - 1128
DOI: 10.1126/science.153.3740.1127
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Articles

Diabetes, a New Mutafton in the Mouse

Katharine P. Hummel 1, Margaret M. Dickie 1, and Douglas L. Coleman 1

1 Jackson Laboratory, Bar Harbor, Maine

Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.


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The Leptin Receptor.
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Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males.
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Endocrinology 138, 1190-1193
   Abstract »    Full Text »    PDF »
Mitotic Division in Pancreatic Beta Cells.
A. A. Like and W. L. Chick (1969)
Science 163, 941-943
   Abstract »    PDF »
Diabetes Mellitus in Man and Experimental Animals.
G. F. CAHILL JR. (1967)
Ann Intern Med 66, 227-230
   Abstract »    PDF »


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