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Science 2 September 1966:
Vol. 153. no. 3740, pp. 1122 - 1123
DOI: 10.1126/science.153.3740.1122
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Articles

Heat-Labile Serum Factor Required for Immunofluorescence of Polyoma Tumor Antigens

Kenneth K. Takemoto 1, Richard A. Malmgren 2, and Karl Habel 3

1 Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
2 Pathologic Anatomy Branch, National Cancer Institute
3 Laboratory of Biology of Viruses

The immunofluorescent demonstration of polyoma tumor antigens in tumor cells requires a heatlabile serum component. With unheated hamster tumor serum, specific fluorescence was observed in polyoma-transformed hamster, mouse, and rat tumor cells. Heated serum usually gave little or no reactivity; the activity of such heated serum could be restored simply by the addition of fresh normal unheated hamster serum.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)