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Science 26 August 1966:
Vol. 153. no. 3739, pp. 1017 - 1018
DOI: 10.1126/science.153.3739.1017
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Articles

Amnesia or Reversal of Forgetting by Anticholinesterase, Depending Simply on Time of Injection

J. A. Deutsch 1 and Sarah Fryer Leibowitz 2

1 Department of Psychology, University of California, San Diego
2 Department of Psychology, New York University, New York

The effect of intracerebral injections of the anticholinesterase drug diisopropyl fluorophosphate in rats was to produce good recall of an otherwise almost forgotten habit learned 28 days before. The same injections produced temporary amnesia for the same habit, otherwise well remembered, learned 14 days before. The injections had no ef fect on the memory of the same habit when it was only partly learned 14 days before. The results support the hy pothesis that the physiological basis of memory lies in an increase, and for getting in a decrease, in synaptic con ductance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Cholinergic Synapse and the Site of Memory.
J. A. Deutsch (1971)
Science 174, 788-794
   Abstract »    PDF »
Retrograde Amnesia Produced by Intraperitoneal Injection of Physostigmine.
M. D. Hamburg (1967)
Science 156, 973-974
   Abstract »    PDF »


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