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Science 26 August 1966:
Vol. 153. no. 3739, pp. 1000 - 1002
DOI: 10.1126/science.153.3739.1000
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Articles

Bipiperidyl Mustard, A New Obesifying Agent in the Mouse

Robert J. Rutman 1, Florence S. Lewis 1, and William D. Bloomer 1

1 Department of Chemistry, University of Pennsylvania, Philadelphia 19104

Bipiperidyl mustard, after conversion to its bis-cyclic immonium ion forme, has been found to cause rapid and extensive lipid deposition in mice given single doses of the drug. The obe sity appears to result from an alkylation reaction; the responses of the treated ani mals to food restriction and realimenta tion resemble those observed in gold thioglucose-treated mice; also in anal ogy to gold thioglucose, the bipiperidyl mustard effects can be counteracted by sulfhydryl compounds. These observa tions are suggestive of a similarity of mode of action between the alkylating agent and gold thioglucose, a conclusion which is supported by preliminary find ings of ventromedial lesions in the hypo thalamus of the bipiperidyl mustard treated mice.


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