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Science 24 June 1966:
Vol. 152. no. 3730, pp. 1761 - 1763
DOI: 10.1126/science.152.3730.1761
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Articles

Cytochemical Localization of Lactate Dehydrogenase in Muscular Dystrophy of the Mouse

H. D. Fahimi 1 and P. Roy 1

1 Channing Laboratory, Boston City Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts

By use of phenazine methosulfate and the "ncubation mixture film method," lactate dehydrogenase activity has been demonstrated in the dystrophic muscle fibers of strain 129 mice. The results indicate that for demonstration of lactate dehydrogenase activity in dystrophic muscle fibers phenazine methosulfate is necessary. This finding is typical for the "white" muscle fibers in the normal muscle and suggests that the dystrophy affects primarily the "white" muscle fibers.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)