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Science 17 June 1966:
Vol. 152. no. 3729, pp. 1630 - 1631
DOI: 10.1126/science.152.3729.1630
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Tritiated Norepinephrine: Release from Brain Slices by Electrical Stimulation

Ross J. Baldessarini 1 and Irwin J. Kopin 1

1 National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

Slices of rat brain and heart that had concentrated H3-norepinephrine were superfused and electrically stimulated. Stimulation induced a marked release of H3-norepinephrine with a threshold and a maximum repsonse. Release also occurred with increased concentrations of potassium, presumably due to neuronal depolarization. Inhibition of electrically induced release occurred with low calcium and with chlorpromazine and pentobarbital.


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